FITC标记的羟酰谷胱甘肽水解酶蛋白抗体
产品名称： FITC标记的羟酰谷胱甘肽水解酶蛋白抗体
英文名称： Anti-HAGH/FITC
产品编号： HZ-15404R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HAGH/FITC Conjugated antibody
FITC标记的羟酰谷胱甘肽水解酶蛋白抗体
| 英文名称 | Anti-HAGH/FITC |
| 中文名称 | FITC标记的羟酰谷胱甘肽水解酶蛋白抗体 |
| 别 名 | GLO2; GLX II; Glyoxalase II; HAGH; HAGH1; Hydroxyacyl glutathione hydrolase; Hydroxyacylglutathione hydrolase, mitochondrial; GLO2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 新陈代谢 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HAGH |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I and Gyloxalase II (also designated hydroxyacyl glutathione hydrolase or HAGH) are members of the Gyloxalase family. The Gyloxalase II enzyme is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form reduced glutathione and D-lactic acid. It exists only as a monomer and binds two zinc ions per subunit. Glyoxalase II contains 260 amino acids. It is detected in the mitochondria and cytosol of mammals. Both Glyoxalase I and Gyloxalase II are detected at a higher activity level in breast cancer tissues than with matched unaffected tissues. This suggests that glyoxalase inhibitor drugs may be effective in the treatment of cancer. Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. Subunit: Monomer. Subcellular Location: Isoform 1: Mitochondrion matrix. Isoform 2: Cytoplasm. Tissue Specificity: Expressed in liver and kidney. Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. Database links: Entrez Gene: 3029 Human Entrez Gene: 14651 Mouse Entrez Gene: 24439 Rat Omim: 138760 Human SwissProt: Q16775 Human SwissProt: Q99KB8 Mouse SwissProt: O35952 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
乙二醛途径在葡萄糖降解产物（GDP）的解毒中起作用。乙醛酸酶I和Gyloxalase II（也被指定为羟酰基谷胱甘肽水解酶或HAGH）是Gyloxalase家族的成员。Gyloxalase II酶是催化S-D-乳酰基谷胱甘肽水解生成还原型谷胱甘肽和D-乳酸的硫酯酶。它仅存在于单体中并结合两个亚基的两个锌离子。乙二醛酶II含有260个氨基酸。它在哺乳动物的线粒体和细胞质中被检测到。与匹配的未受影响的组织相比，在乳腺癌组织中，乙二醛酶I和Gyloxalase II的活性水平更高。这表明，乙醛酸酶抑制剂药物可能是有效的治疗癌症。