SREBF1 monoclonal antibody (M03), clone 4G4
产品名称: SREBF1 monoclonal antibody (M03), clone 4G4
英文名称: SREBF1 monoclonal antibody (M03), clone 4G4
产品编号: H00006720-M03
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant SREBF1.
- Immunogen:
- SREBF1 (AAH57388, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- VTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
- MSDS:
- Download
- Applications
- Western Blot (Cell lysate)
- SREBF1 monoclonal antibody (M03), clone 4G4 Western Blot analysis of SREBF1 expression in HeLa ( Cat # L013V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged SREBF1 is approximately 0.03ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 6720
- GeneBank Accession#:
- BC057388
- Protein Accession#:
- AAH57388
- Gene Name:
- SREBF1
- Gene Alias:
- SREBP-1c,SREBP1,bHLHd1
- Gene Description:
- sterol regulatory element binding transcription factor 1
- Omim ID:
- 184756
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- sterol regulatory element binding protein-1
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Cardiovascular Diseases
- Coronary Artery Disease
- Coronary Disease
- Dementia
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression
- Drug Toxicity
- Edema