FITC标记的5-羟色胺受体5B抗体
产品名称： FITC标记的5-羟色胺受体5B抗体
英文名称： Anti-5HT5B Receptor/FITC
产品编号： HZ-13779R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-5HT5B Receptor/FITC Conjugated antibody
FITC标记的5-羟色胺受体5B抗体
| 英文名称 | Anti-5HT5B Receptor/FITC |
| 中文名称 | FITC标记的5-羟色胺受体5B抗体 |
| 别 名 | 5 HT 5B; 5 HT5B; 5 hydroxytryptamine receptor 5B; 5ht5b; Htr5b; REC17; Serotonin receptor 5B; 5HT5B_MOUSE. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse 5HT5B Receptor |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SR-5B, also designated 5-hydroxytryptamine (serotonin) receptor 5B (5-HT5B) and G protein-coupled receptor 134 (GPR134), is a receptor for the monoamine ligand serotonin (5-hydroxytryptamine, 5-HT). Serotonin is a neurotransmitter derived from serotonergic neurons in the central nervous system and entero-chromaffin cells in the gastrointestinal tract. Serotonin actions are mediated by receptors that influence the biochemistry of depression, anxiety, sexuality and appetite. Rat SR-5B is present in serotonergic neurons in dorsal raphe (DR) and central superior nucleus (CS, median raphe nucleus). DR cell bodies showing SR-5B mRNA expression are abundant in the medial portions of the nucleus. CS coexpression of SR-5B receptor mRNA with serotonin transporter mRNA is high in the intermediate portions of the nucleus. Serotonin receptors include SR-1–7 (5-HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. Subtypes within the SR-2 group include SR-2A, -2B and -2C. Subtypes within the SR-5 group include SR-5A and -5B. SR receptors can couple to G proteins that act on either adenylate cyclase or phospholipase C (PLC). The SR-3 class of receptors are ion channels. Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed predominantly in the central nervous system; in the hippocampus, habenula, and the doral raphe. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 15564 Mouse Entrez Gene: 79247 Rat SwissProt: P31387 Mouse SwissProt: P35365 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SR-5B，也称为5-羟色胺(5-HT5B)受体5B和G蛋白偶联受体134(GPR134)，是单胺配体5-羟色胺(5-羟色胺，5-HT)的受体。5-羟色胺是一种神经递质，来源于中枢神经系统中的5-羟色胺能神经元和胃肠道中的肠嗜铬细胞。5-羟色胺的作用是由影响抑郁症、焦虑、性欲和食欲的生物化学受体介导的。大鼠SR-5B存在于中缝背核（DR）和中央上核（CS中缝核）的5-羟色胺能神经元中。DR细胞体显示SR -5B mRNA的表达在细胞核的内侧部分丰富。SR -5B受体mRNA与5-羟色胺转运体mRNA的共表达在细胞核的中间部分较高。5-羟色胺受体包括SR-1 - 7（5-HT1 - 7）。SR-1组内的亚型包括SR-1A、-1B、-1D、-1E和-1F。SR-2组内的亚型包括SR-2A、-2B和-2C。SR-5组内的亚型包括SR-5A和-5B。SR受体可以与作用于腺苷酸环化酶或磷脂酶C(PLC)的G蛋白偶联。SR-3类受体是离子通道。