The Human Glioma qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human glioma tumor DNA. Glioma, a common primary malignant brain tumor, arises from glial cells in part due to acquired genetic alterations in cell cycle, signal transduction, transcription factors, and other genes that regulate glial cell proliferation and differentiation. Based on the primary literature and public databases, genes were chosen from the most frequently amplified or deleted genes in various forms of glioma including glioblastomas, medulloblastomas, oligodendrogliomas, pilocytic astrocytomas, and proneural gliomas. This array may serve as a useful tool to help classify glioma samples by genotype and help verify glioma phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.

The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available

神经胶质瘤qBiomarker拷贝数PCR芯片用于研究已报道的在人类神经胶质肿瘤DNA发生频繁基因突变的23个基因的拷贝数。神经胶质瘤，常见的原发性恶性脑瘤,起源于神经胶质细胞，部分原因在于细胞周期、信号转导、转录因子等基因的突变，好包括调节神经胶质细胞增殖和分化的其他基因。基于文献和公共数据库,基因来自各种形式的神经胶质瘤包括恶性胶质瘤,成神经管细胞瘤,少突神经胶质瘤,pilocytic星形细胞瘤、颈板神经胶质瘤等最频繁扩增或缺失的基因。该芯片可作为分类神经胶质瘤样本基因型和验证神经胶质瘤表型生物标记的有效工具。这个芯片可以使每个基因在每个样本中有四个重复，同时包含一个稳定的多拷贝参考实验，通过适当的DNA插入标准化精确检测拷贝数。简单的产品模式和操作程序让任何一个具备实时定量PCR仪的实验室都可进行常规可靠的拷贝数检测。

qBiomarker拷贝数PCR芯片用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。

提供96孔板，384 -(4×96)板，和100 孔。

Gliomas: CCND3, CHD5, LNX1, LRRN2, NOG, NUMBL, SOX8.

Glioblastomas: IL6, NFKBIA, SEC61G, TNFSF13B.

Medulloblastomas: KDM4C, KDR.

Oligodendrogliomas: CDC42, CDKN2C.

Pediatric: ADAM3A, PDGFRB.

Pilocytic Astrocytomas: HIPK2.

Proneural Gliomas: DLL3, GLIS3, HEY2, TGFB2, TNC