FITC标记的着丝粒ZWILCH蛋白抗体
产品名称： FITC标记的着丝粒ZWILCH蛋白抗体
英文名称： Anti-ZWILCH/FITC
产品编号： HZ-9732R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ZWILCH/FITC Conjugated antibody
FITC标记的着丝粒ZWILCH蛋白抗体
| 产品编号 | bs-9732R-FITC |
| 英文名称 | Anti-ZWILCH/FITC |
| 中文名称 | FITC标记的着丝粒ZWILCH蛋白抗体 |
| 别 名 | hZwilch; KNTC1AP; MGC111034; Protein zwilch homolog; ZWILC_HUMAN; zwilch;y ZWILCH protein; Zwilch, kinetochore associated, homolog. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZWILCH |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells. Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Subunit: Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts directly with KNTC1/ROD. Component of the NRZ complex composed of ZWILCH, KNTC1/ROD, RINT1, ZW10 and NBAS. Subcellular Location: Chromosome, centromere, kinetochore. Database links: Entrez Gene: 55055 Human Entrez Gene: 68014 Mouse Omim: 609984 Human SwissProt: Q9H900 Human SwissProt: Q8R060 Mouse Unigene: 21331 Human Unigene: 335237 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
zwilch是人类同源的果蝇zwilch蛋白。这是一个复杂的果蝇zwilch窗体杆粗的交易）和（10 zwint Zeste白色，所以指定zw10）的蛋白质。这是复杂的，因为它重要的染色体分离和胞质动力蛋白的着丝点recruits扮演关键角色A在主轴检查站。在复杂的角色zwilch是思想的evolutionarily conserved因为人力zwilch同系物），zwint和杆coimmunoprecipitate在HeLa细胞线，称为a人。人力zwilch zwint杆，和复杂的localizes到着丝粒在早中期。突变被发现在一zwilch和杆，zwint屏幕突变等位基因编码推定的基因在染色体的不稳定性在人类结直肠肿瘤的情况。论文以一个突变可能在结直肠肿瘤细胞表型的染色体不稳定性）。