FITC标记的心肌病相关蛋白2抗体
产品名称： FITC标记的心肌病相关蛋白2抗体
英文名称： Anti-CMYA2/PDE4DIP/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-CMYA2/PDE4DIP/FITC Conjugated antibody
FITC标记的心肌病相关蛋白2抗体
| 产品编号 | bs-9477R-FITC |
| 英文名称 | Anti-CMYA2/PDE4DIP/FITC |
| 中文名称 | FITC标记的心肌病相关蛋白2抗体 |
| 别 名 | Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 信号转导 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 265kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events. Function: May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Subunit: Interacts with PDE4D (By similarity). Subcellular Location: Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. DISEASE: Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein. Similarity: Contains 1 NBPF domain. Database links: Entrez Gene: 9659 Human Entrez Gene: 83679 Mouse Entrez Gene: 64183 Rat Omim: 608117 Human SwissProt: Q5VU43 Human SwissProt: Q80YT7 Mouse SwissProt: Q9WUJ3 Rat Unigene: 584841 Human Unigene: 613082 Human Unigene: 657490 Human Unigene: 728768 Human Unigene: 129840 Mouse Unigene: 48693 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
可以作为锚定螯合成分的cAMP依赖的途径Golgi和/或中心体。肌球蛋白是一种含有2346个氨基酸的蛋白质，含有一个NBPF结构域，定位于细胞核、细胞质、中心体和高尔基体。在胎儿和心脏和在脑和胎盘的较低水平上表达，肌球蛋白被认为是锚定蛋白的功能，将cAMP依赖性通路的成员与高尔基体和中心体隔离，从而介导cAMP通路动力学。编码肌球蛋白的基因中的易位与骨髓增生性疾病（MDS）有关，这是由血细胞过度生成引起的一组疾病。肌球蛋白作为十二种异构体存在，由于选择性剪接事件。