目前肿瘤分子诊断技术中,需要通过手术或穿刺获取组织样本,具有对病人产生创伤,无法进行动态监测等局限性。随着“液体活检”技术发展,循环肿瘤DNA (ctDNA) 等无创检测技术已逐渐从科学研究走向了临床诊断。“液体活检”从血浆为代表的体液样本获得游离核酸,进而应用于肿瘤早期诊断,靶向药物的选择以及动态疗效监测等。QIAGEN 的液体活检解决方案,灵敏迅速地分析游离核酸(ctDNA),结合下游一系列基于PCR、NGS的完整检测分析方案,引领疾病研究中液体活检的革命。
Illumina-compatible:
cfDNA WGS |
·PAXgene Blood ccfDNA Tubes |
·QIAamp/ QIAsymphony Circulating NA Kit |
· GeneRead DNA Library I Kit (96) · QIAseq Ultra Low Input Library Kit |
Any Illumina Sequencer (MiSeq、 HiSeq、 NextSeq) |
·IVA · IPA · QIAGEN Clinical Insight · Biomedical Workbench · Genomics Workbench |
cfDNA Panels |
· PAXgene Blood ccfDNA Tubes |
·QIAamp/ QIAsymphony Circulating NA Kit |
· GeneRead DNA Panels V2 · QIAseq 1-Step Amplicion Library Kit (96) |
Any Illumina Sequencer (MiSeq、 HiSeq、 NextSeq) |
· IVA • IPA • QIAGEN Clinical Insight • BiomedicalWorkbench •Genomics Workbench |
Ion-compatible:
cfDNA WGS |
·PAXgene Blood ccfDNA Tubes |
·QIAamp Circulating NA Kit ·QIAsymphony |
· GeneRead DNA L Core Kit (96) · GeneRead DNA L Amp Kit (96) · GeneRead Adapter L Kit |
Any Ion Sequencer (PGM、 Proton、 Ion S5) |
·IVA · IPA · QIAGEN Clinical Insight · Biomedical Workbench · Genomics Workbench |
cfDNA Panels |
· PAXgene Blood ccfDNA Tubes |
•QIAamp Circulating NA Kit · QIAsymphony |
· GeneRead DNA Panels V2 • GeneRead DNA L Core Kit (96) • GeneRead DNA L Amp Kit (96) • GeneRead Adapter L Kit 12-plex |
Any Ion Sequencer (PGM、 Proton、 Ion S5) |
· IVA • IPA • QIAGEN Clinical Insight • Biomedical Workbench • Genomics Workbench |
在游离核酸之外,QIAGEN在液体活检的循环肿瘤细胞(CTC)、外泌小体(Exosomes)等领域也有十分全面的解决方案。QIAGEN的AdnaTest CTC检测产品及REPLI-g单细胞扩增产品在业内一直占有十分重要的地位,解决了CTC前期分离、分析检测以及起始样本量低的问题,适合于下游进行全面而灵活的多种分析方案。此外,全新推出的mi Single Cell qPCR Kit从根源上解决单细胞miRNA研究的瓶颈问题,结合QIAGEN下游十分丰富的检测产品线,将miRNA检测分析带入了全新的时代。
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